Role of Descending Dopaminergic Pathways in Pain Modulation
نویسندگان
چکیده
منابع مشابه
Nicotinic modulation of descending pain control circuitry.
Along with the well-known rewarding effects, activation of nicotinic acetylcholine receptors (nAChRs) can also relieve pain, and some nicotinic agonists have analgesic efficacy similar to opioids. A major target of analgesic drugs is the descending pain modulatory pathway, including the ventrolateral periaqueductal gray (vlPAG) and the rostral ventromedial medulla (RVM). Although activating nAC...
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The endogenous antinociceptive descending pathway represents a circuitry of the supraspinal central nervous system whose task is to counteract pain. It includes the periaqueductal grey (PAG)-rostral ventromedial medulla (RVM)-dorsal horn (DH) axis, which is the best characterized pain modulation system through which pain is endogenously inhibited. Thus, an alternative rational strategy for sile...
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ژورنال
عنوان ژورنال: Current Neuropharmacology
سال: 2019
ISSN: 1570-159X
DOI: 10.2174/1570159x17666190430102531